Predicting Post-Surgery T2D Remission; Infertility & Strokes; Cold Thwarts Obesity?

Testing blood levels of ceramides after Roux-en-Y gastric bypass surgery helped to predict exactly which patients may achieve type 2 diabetes remission within the 2 years after surgery. "[These findings] reveal a new tool in the physician's arsenal for managing the health of the increasing number of people undergoing bariatric surgery," said study author Scott Summers, PhD, of the University of Utah Diabetes Metabolism Research Center in Salt Lake City. (Med)

Looking at data on over 600,000 women, having a history of three or more recurrent miscarriages was linked with a 35% higher risk for non-fatal and fatal stroke. Similarly, infertility was linked with a 14% higher stroke risk. (The BMJ)

In stage B heart failure, uncontrolled diabetes -- defined as an HbA1c of 7% or higher -- was linked with over a 7.5-fold higher risk for heart failure progression. (Journal of the American College of Cardiology)

Kids conceived via medically assisted reproduction, like IVF, were more likely to face mental health issues as teenagers. "The fact that we observe an increased risk of mental health disorders once we account for family characteristics could be a cause for concern and merits further attention in future research," said Alice Goisis, PhD, of the University College London Centre for Longitudinal Studies. (European Journal of Population)

Exposure to cold temperatures might be able to improve obesity-related inflammation, insulin sensitivity, and glucose tolerance, a mouse study found. (Nature Metabolism)

The World Health Organization said it's kicking off a new series of policy dialogues aimed at fighting obesity.

The American Diabetes Association's 2022 Standards of Medical Care in Diabetes gave finerenone (Kerendia) a grade A recommendation for cardiovascular outcomes and reducing risk of chronic kidney disease progression in patients with type 2 diabetes, Bayer announced.

A phase Ib study of the investigational once-weekly GLP-1 and glucagon receptor dual agonist IBI362 was both safe and tolerable in a study of Chinese patients with type 2 diabetes. (Nature Communications)

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